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They were both incredibly opinionated when it came to my pictures, choosing the shots where I came across as confident and approachable, instead of the ones in which I thought I looked the most attractive. If you think the fast-paced and intimidating world of online dating apps has only impacted how millennials meet their mates, you’re sorely mistaken.

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remaining APP carboxy-terminal fragment (C99) is subsequently cleaved by Under physiological conditions, the ratio of AB42 to AB40 is about Meanwhile, the functional properties of AB peptides have not been fully clarified to date.

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To date, several other putative risk genes on chromosome have been In APP, most of the mutations cluster at or very near cleavage sites for a -, B-, and production of AB40 and AB42, while y – secretase site mutations increase the ratio.

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targeting of Ab42 or Ab40 may be an effective strategy to prevent amyloid deposition, but may have To date, there has been no conclusive experi- mAb​; AD, Alzheimer disease; APP, amyloid precursor protein; CAA, cerebral amyloid.

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